To compare an accelerated high-dose (500 mg) vs low-dose (200 mg) regimen of intravenous iron sucrose in a cohort of iron-deficient anemic antenatal patients in terms of efficacy, safety, and compliance.

In a prospective hospital-based study, antenatal and postnatal women with anemia attending Jawaharlal Nehru Medical College and Hospital, Aligarh, India, between December 2010 and December 2012 were enrolled. The inclusion criteria were all outpatient and admitted anemic antenatal women ≤ 36 weeks gestation and postnatal women with hemoglobin (Hb) below 10 gm/dL, or serum ferritin ≤ 30 μg/L or transferrin saturation ≤ 40% irrespective of prior oral iron therapy. Patients were excluded from the study if they were hemodynamically unstable, actively bleeding, having fever, or were nauseated or vomiting. Participants were assigned to control and study groups according to simple random sampling. Intravenous iron sucrose group I (500 mg)/group II (200 mg) was infused after test dose on alternate days for the calculated total dose in the study population. Blood and iron indices were measured at baseline and after 2 weeks of administration of last dose. The primary outcome of the study was to assess the rise in Hb and safety of high-dose intravenous iron sucrose.

There was a statistically significant increase in Hb level in patients receiving either regimen, with larger mean increase in group I (2.7 ± 0.4) compared with group II (2.25 ± 6.39). Serum iron and serum ferritin also increased in both fortnightly (p < 0.001). Blood transfusion was avoided by 90.1% in severely anemic cases with Hb < 7. Hospital stay was reduced by 50% in group I.

The accelerated regimen of high-dose (500 mg) intravenous iron sucrose in anemic antenatal patients appears to be safe and effective in correcting anemia, restoring iron stores, and avoiding blood transfusion.

Anjum S, Garg N, Beriwal S, Parvez A. High-dose Accelerated vs Low-dose Frequent Regime of Iron Sucrose Therapy in Antenatal and Postnatal Women with Iron Deficiency. World J Anemia 2017;1(2):31-35.

Munshi A, Munshi S. Iron Deficiency Anemia in Pregnancy: Can We eradicate? World J Anemia 2017;1(2):36-39.

Prasanth R. Prevalence of Anemia in both Developing and Developed Countries around the World. World J Anemia 2017;1(2):40-43.

Gupta S, Gupta S, Swarup N, Sairam H, Sinha N, Nair SS. Orofacial Manifestations associated with Anemia. World J Anemia 2017;1(2):44-47.

Swarup N, Gupta S, Sagolsem C, Chowdhary Z, Gupta S, Sinha N. Atrophic Glossitis: Burning Agony of Nutritional Deficiency Anemia. World J Anemia 2017;1(2):48-50.

Saxena R, Bhatia A, Midha K, Debnath M, Kaur P. Malaria: A Cause of Anemia and Its Effect on Pregnancy. World J Anemia. 2017;1(2):51-62.

Acharya S, Shukla S, Jamthe A, Tamhane A. Sickle Cell Anemia with Megaloblastic Crisis: Deficiency or Demand? World J Anemia 2017;1(2):63-64.

The aim of this article is to report a rare case of chronic abruption-oligohydramnios sequence (CAOS).

Abruptio placentae is usually an acute event needing emergent measures for management, but may present with varied clinical features.

We describe a rare case of a 20-year-old primigravida at 16 weeks of gestation who presented with complaints of mild pain abdomen off and on for 1 month and minimal bleeding per vaginum for a day. Her vital signs were stable, but there was marked pallor. Obstetric examination revealed uterus corresponding to 20 to 22 weeks of gestation with raised basal tone. Ultrasound findings showed a dead fetus corresponding to 16 weeks of gestation with a large retroplacental collection of 12.5 × 7 cm. The patient was given three units of blood transfusion after which the patient went into spontaneous labor and delivered uneventfully 23 hours after admission.

Recognition of chronic abruption and prompt intervention in our case led to a favorable maternal outcome.

The diagnosis of chronic abruption should be kept in mind in patients presenting with pain abdomen even in early pregnancy.

Chopra K. A Rare Case of Chronic Abruption-oligohydramnios Sequence at 16 Weeks Pregnancy with Compensated Severe Anemia. World J Anemia 2017;1(2):65-67.