World Journal of Anemia

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VOLUME 2 , ISSUE 3and4 ( July-December, 2018 ) > List of Articles


Nutritional Anemia in Geriatric Population

Richa Saxena, Nidhi Sood

Keywords : Aged population, Anemia, Hematological changes, Malnutrition, Nutritional deficiency

Citation Information : Saxena R, Sood N. Nutritional Anemia in Geriatric Population. World J Anemia 2018; 2 (3and4):103-106.

DOI: 10.5005/jp-journals-10065-0040

License: CC BY-NC 4.0

Published Online: 01-04-2020

Copyright Statement:  Copyright © 2018; The Author(s).


Anemia is a rapidly growing cause of concern among the aged population (age older than 65 years) in the world today. It is often multifactorial and remains underdiagnosed, especially in case of nutritional anemia because of its ability to stay insidious for a long period. Furthermore, it has been predicted that the population of the elderly is continually increasing due to the advancements in medical technology and healthcare system, better access to medical facilities and due to enhanced awareness to live a healthy lifestyle. All these factors contribute to increased longevity in the elderly. This is also one of the reasons for increased burden on the healthcare system, as this segment of population is the most vulnerable for developing serious medical conditions such as anemia. Anemia is natural consequence of the process of aging and poses high risk of developing diseases in the older people along with decline in physical performance, increased morbidity and poor quality of life. This article aims at providing useful insights into various factors responsible for developing nutritional anemia. It also aims to provide understanding of relationship between aging and anemia, and summarizes recent management options available for nutritional anemia in the aged population.

  1. Andrès E 2018. Nutritional Anemia in Elderly Patients of Developed Countries. Current Topics in Anemia. [online] Available from [Last accessed December, 2019].
  2. Guralnik JM, Eisenstaedt RS, Ferrucci L, et al. Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia. Blood 2004;104(8):2263–2268. DOI: 10.1182/blood-2004-05-1812.
  3. Stauder R, Valent P, Theurl I. Anemia at older age: etiologies, clinical implications, and management. Blood 2018;131(5):505–514. DOI: 10.1182/blood-2017-07-746446.
  4. Andrès E, Serraj K, Federici L, et al. Anemia in elderly patients: new insight into an old disorder. Geriatr Gerontol Int 2013;13(3):519–527. DOI: 10.1111/ggi.12017.
  5. Emiroglu C, Görpelioglu S, Aypak C. The relationship between nutritional status, anemia and other vitamin deficiencies in the elderly receiving home care. J Nutr Health Aging 2019;23(7):677–682. DOI: 10.1007/s12603-019-1215-9.
  6. Gaskell H, Derry S, Moore RA, et al. Prevalence of anaemia in older persons: systematic review. BMC Geriatr 2008;8(1):1. DOI: 10.1186/1471-2318-8-1.
  7. Vanasse GJ, Berliner N. Anemia in elderly patients: an emerging problem for the 21st century. Hematology Am Soc Hematol Educ Program 2010;2010(1):271–275. DOI: 10.1182/asheducation-2010.1.271.
  8. Busti F, Campostrini N, Martinelli N, et al. Iron deficiency in the elderly population, revisited in the hepcidin era. Front Pharmacol 2014;5:83. DOI: 10.3389/fphar.2014.00083.
  9. Fairweather-Tait SJ, Wawer AA, Gillings R, et al. Iron status in the elderly. Mech Aging Develop 2014;136:22–28. DOI: 10.1016/j.mad.2013.11.005.
  10. Steensma DP, Tefferi A. Anemia in the elderly: how should we define it, when does it matter, and what can be done? Mayo Clin Proceed 2007;82(8):958–966. DOI: 10.4065/82.8.958.
  11. Patel KV. Epidemiology of anemia in older adults. Semin Hematol 2008;45(4):210–217. DOI: 10.1053/j.seminhematol.2008.06.006.
  12. Artz AS, Thirman MJ. Unexplained anemia predominates despite an intensive evaluation in a racially diverse cohort of older adults from a referral anemia clinic. J Gerontol Series A: Biomed Sci Med Sci 2011;66(8):925–932. DOI: 10.1093/gerona/glr090.
  13. Röhrig G, Becker I, Schulz RJ, et al. Association between hematologic parameters and functional impairment among geriatric inpatients: data of a prospective cross-sectional multicenter study (“Geri Prävalenz 2013”). Maturitas 2016;90:37–41. DOI: 10.1016/j.maturitas.2016.04.020.
  14. Girelli D, Marchi G, Camaschella C. Anemia in the elderly. Hema Sphere 2018;2(3):e40. DOI: 10.1097/HS9.0000000000000040.
  15. Mitrache C, Passweg J, Libura J, et al. Anemia: an indicator for malnutrition in the elderly. Ann Hematol 2001;80(5):295–298. DOI: 10.1007/s002770100287.
  16. Ezekowitz JA, McAlister FA, Armstrong PW. Anemia is common in heart failure and is associated with poor outcomes: insights from a cohort of 12,065 patients with new-onset heart failure. Circulation 2003;107(2):223–225. DOI: 10.1161/01.CIR.0000052622.51963.FC.
  17. Wu WC, Rathore SS, Wang Y, et al. Blood transfusion in elderly patients with acute myocardial infarction. N Engl J Med 2001;345(17):1230–1236. DOI: 10.1056/NEJMoa010615.
  18. Andrès E. Oral cobalamin (vitamin B12) therapy: from empiricism and personal experience to evidence based medicine and perspective of recommendations and guideline. J Blood Disord Transfus 2012;3:E102. DOI: 10.4172/2155-9864.1000e102.
  19. Röhrig G. Anemia in the frail, elderly patient. Clin Interven Aging 2016;11:319. DOI: 10.2147/CIA.S90727.
  20. Smith DL. Anemia in the elderly. Iron disorders institute guide to anemia 2009. vol. 9 pp. 96–103.
  21. Andrès E, Affenberger S, Vinzio S, et al. Food-cobalamin malabsorption in elderly patients: clinical manifestations and treatment. Am J Med 2005;118(10):1154–1159. DOI: 10.1016/j.amjmed.2005.02.026.
  22. Rimon E, Levy S, Sapir A, et al. Diagnosis of iron deficiency anemia in the elderly by transferrin receptor–ferritin index. Arch Intern Med 2002;162(4):445–449. DOI: 10.1001/archinte.162.4.445.
  23. Federici L, Loukili NH, Zimmer J, et al. Hematologic evidence of vitamin B12 deficiency: personal data and review of literature. J Intern Med 2007;28(4):225–231.
  24. Carmel R. Diagnosis and management of clinical and subclinical cobalamin deficiencies: why controversies persist in the age of sensitive metabolic testing. Biochimie 2013;95(5):1047–1055. DOI: 10.1016/j.biochi.2013.02.008.
  25. Frangos E, Trombetti A, Graf CE, et al. Malnutrition in very old hospitalized patients: A new etiologic factor of anemia? J Nutr Health Aging 2016;20(7):705–713. DOI: 10.1007/s12603-015-0641-6.
  26. Long B, Koyfman A. Emergency medicine evaluation and management of anemia. Emerg Med Clin 2018;36(3):609–630. DOI: 10.1016/j.emc.2018.04.009.
  27. Goodnough LT, Schrier SL. Evaluation and management of anemia in the elderly. Am J Hematol 2014;89(1):88–96. DOI: 10.1002/ajh.23598.
  28. Locatelli F, Del Vecchio L. Erythropoiesis-stimulating agents in renal medicine. Oncologist 2011;16(Suppl 3):19–24. DOI: 10.1634/theoncologist.2011-S3-19.
  29. Matzner Y, Levy S, Grossowicz N, et al. Prevalence and causes of anemia in elderly hospitalized patients. Gerontology 1979;25(2):113–119. DOI: 10.1159/000212328.
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