World Journal of Anemia

Register      Login

VOLUME 2 , ISSUE 3and4 ( July-December, 2018 ) > List of Articles


Study of Increase in Hemoglobin Concentration after Administration of Intravenous Iron Sucrose in Pregnant Women with Severe Anemia

Anita Kumari, Sangeeta Rai, Shyama

Keywords : Intravenous iron-sucrose, Pregnancy, Severe anemia

Citation Information : Kumari A, Rai S, S. Study of Increase in Hemoglobin Concentration after Administration of Intravenous Iron Sucrose in Pregnant Women with Severe Anemia. World J Anemia 2018; 2 (3and4):79-84.

DOI: 10.5005/jp-journals-10065-0039

License: CC BY-NC 4.0

Published Online: 01-02-2020

Copyright Statement:  Copyright © 2018; The Author(s).


Introduction: Iron-deficiency anemia is a great concern among obstetricians. Anemic women are at a greater risk of dying during their pregnancy. Despite the measures taken to control anemia in pregnancy in the last two decades, the severity of nutritional anemia continues to remain a public health issue of great magnitude. Oral supplement or iron has several drawbacks. Hence an idea was conceptualized to conduct a study to evaluate the efficacy of IV iron sucrose (OROFER-S) in the improvement of hemoglobin concentration in the antenatal mothers with severe anemia. Materials and methods: This progressive study was conducted in antenatal OPD of obstetrics and gynecology department of VSS Medical College, Burla, Odisha for a period of 24 months. Results: Out of 23 antenatal mothers with severe anemia, 73.91% were residing in rural area and 26.08% were residing in urban area. The cases recruited in the study were given a total of 300 mg elemental iron as iron sucrose complex diluted in 0.9% of NS per week. Hemoglobin level was estimated at the onset and again two weeks after the completion of the study. On completion of therapy, there was significant improvement in Hb level with a rise of Hb level (2.5–3) in 4.3% mothers, and (1.5–2) g/dL in 60.66% cases. No rise in Hb level was observed in 8.6% cases. Present study shows correlation between severity of anemia and gravidity with multigravida accounting for 65.21%. Most of the patients (39.13%) were just literate or had primary education (26.08%). The study groups faced only minor side effects like nausea (21.73%), shivering (13.04%), no serious anaphylactic reactions were observed. Low birth weight (47.82%) is the most common fetal complication. Further IUGR accounts for 34.78% and premature labor (13.04%). Gestational hypertension (21.73%), postpartum hemorrhage (17.39%) and preterm labor (3.90%) and the common maternal complications observed.

  2. Studd J. Progress in Obstetrics and Gynecology, 15th ed., 2002. pp. 104–116.
  3. Desai P, Patel P. Medical Disorders in Pregnancy, 2005. pp. 284–285.
  4. Danielson BG. Structure, chemistry and pharmacokinetics of intravenous iron agents. J Am Soc Nephrol 2004;15(Suppl 2):S93–S98.
  5. injection: Cat; Health.
  6. Jaleel R, Khan A. Severe anaemia and adverse pregnancy outcome. J Surg Pak 2008;13(4):147–150.
  7. Al RA, Unlubilgin E, Kandemir O, et al. Intravenous versus oral iron for treatment of anaemia in pregnancy. Obstet Gynecol 2005;106(6):1335–1340. DOI: 10.1097/01.AOG.0000185260.82466.b4.
  8. Gautam VP, Bansal Y, Taneja DK, et al. Prevalence of anaemia amongst pregnant women and its socio demographic associates in a rural area of Delhi. Indian J Community Med 2002;27(4):157.
  9. Silver SB, Rodgers GM. Parenteral iron therapy options. Am J Hematol 2007;76(1):74–78.
  10. Nesimi Kisioglu A, Ozturk M, Aytul Cakmak Z, et al. Anaemia prevalence and its affecting factors in pregnant women of Isparta Province. Biomed Res 2004;16(1):11–14.
  11. Thangaleela T, Vijayalakshmi P. Prevalence of anaemia in pregnancy. Ind J Nutr Diet 1994;31:26–29.
  12. Shah SN, Baksh A, Rauf A, et al. Incidence of iron deficiency anaemia in rual population of Kashmir. Indian J Public Health 1982;26(3):144–154.
  13. Geelhoed D, Agadzi F, Visser L, et al. Maternal and fetal outcome after severe anaemia in pregnancy in rural Ghana. Acta Obstet Gynecol Scand 2006;85(1):49–55. DOI: 10.1080/00016340500334794.
  14. Scott JM, Govan AD. Anaemia of pregnancy treatment with intravenous iron. 1951. Eur J Obstet Gynecol Reprod Biol 2005;123(Suppl 2): S29–S32. DOI: 10.1016/S0301-2115(05)80404-X.
  15. Bashiri A, Burstein E, Sheiner E, et al. Anaemia during pregnancy and treatment with intravenous iron. Eur J Obstet Gynecol Reprod Biol 2003;110(1):2–7. DOI: 10.1016/S0301-2115(03)00113-1.
  16. Breymann C. Eur J Obstet Gynecol Reprod Biol 2005;123(Suppl 2): S1–S2.
  17. Perewusnyk G, Huch R, Huch A, et al. Parenteral iron therapy in obstetrics: 8 years, experience with iron- sucrose complex. Perinatal physiology Unit, Department of Obstetrics, Zurich University Hospital, Switzerland, 2002.
  18. Lone FW, Qureshi RN, Emanuel F. Maternal anaemia and its impact on perinatal outcome. Trap Med Int Health 2004;9(4):486–490. DOI: 10.1111/j.1365-3156.2004.01222.x.
  19. Malhotra M, Sharma JB, Batra S, et al. Maternal and perinatal outcome in varying degree of anaemia. Int J Gynaecol Obstet 2002;79(2): 93–100. DOI: 10.1016/S0020-7292(02)00225-4.
  20. Rehman A, Ghazanfar B, Soomso N. Effect of maternal anaemia in fetal outcome i.e. Apgar score and birth weight. Pak J Surg Oct 2005;21(2):102–105.
  21. Karasahin E, Cyhan ST, Goktolga U, et al. Maternal anaemia and perinatal outcome. Perinat J 2007;15(3):127–130.
  22. Kurki T, Sivonen A, Renkonen OV, et al. Bacterial vaginosis in early pregnancy and pregnancy outcome. Obstet Gynecol 1992;80(2): 173–177.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.